2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
Palmatine
CAS: 3486-67-7
Molecular Formula: C21H22NO4+
2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium - Names and Identifiers
| Name | Palmatine |
| Synonyms | Palmatin Palmatine BRN 1555498 Berbericinine UNII-G50C034217 Common fibraurea stem O,O-Dimethyldemethyleneberberine 5-21-06-00202 (Beilstein Handbook Reference) 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium Berbinium, 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy- 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo(a,g)quinolizinium Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium 2,3,9,10-tetramethoxyisoquinolino[3,2-a]isoquinolin-7-ium hydrate |
| CAS | 3486-67-7 |
| InChI | InChI=1/C21H20NO4.H2O/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-12H,1-4H3;1H2/q+1 |
2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium - Physico-chemical Properties
| Molecular Formula | C21H22NO4+ |
| Molar Mass | 352.409 |
| Melting Point | 205°C |
| Solubility | Soluble in water, methanol |
| Appearance | White powder |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| MDL | MFCD00221758 |
| Physical and Chemical Properties | Coptis Coptis chinensis Franch from Ranunculaceae |
| Use | Palmatine is the total alkaloid extracted from the stem and root of the plant of anti-hexaceae, the main component is the palm leaf. On a variety of gram-positive, negative bacteria have inhibitory effect, and enhance the role of leukocyte phagocytosis. For the treatment of Upper Respiratory Infections, tonsillitis, enteritis, dysentery, urinary tract infections, surgery and obstetrics and gynecology bacterial infections. In addition, it is still used for eye drops in the treatment of combined membrane inflammation; Irrigation or vaginal treatment of Candida albicans infection. |
2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium - Reference
| Reference Show more | 1. Yan Baoqi, Dong Shuwei, Wang Dongsheng, etc. In vitro toxicity of palmatine on goat endometrial epithelial cells [J]. Chinese Journal of Animal Science and Veterinary Medicine, 2016, 43(012):3239-3244. 2. Zhang Xiaoyu, Li Jia. Simultaneous determination of seven effective components in the wind of gold thread by HPLC-ESI-MS/MS [J]. Chinese Journal of Traditional Chinese Medicine, 2017,32(06):2762-2764. 3. Yan: Yu, Zhang: Yu. Simultaneous determination of five components in jinguolan by HPLC-ESI-MS/MS [J]. Chinese herbal medicines, 2017, 40(002):395-398. 4. LIU Zhenzhen, White Bridge, Xu Hao. Effects of different primary processing methods on contents of five alkaloids in Corydalis yanhusuo [J]. Modern Agricultural Science and Technology 2019 000(022):173-176. 5. Yu Yu, Chen Weijia, Zhao Yan, Zhang Ying, Shi Kun, He Zhongmei, Du Rui. Pharmacokinetics and relative bioavailability of solid dispersions of total alkaloids from Huangteng in mice [J]. Journal of Jilin Agricultural University, 2021,43(01):75-81. 6. Wang, Kun, et al. "Identification of metabolites of palmatine in rats." Rapid Communications in Mass Spectrometry 31.6 (2017): 523-537. 7. Nguyen, Thanh Xuan, et al. "Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride." Journal of Materials Chemistry B 2.41 (2014): 7149-7159.https://doi.org/10.1039/C4TB00876F 8. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https:// 9. [IF=6.331] Thanh Xuan Nguyen et al."Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride."J Mater Chem B. 2014 Oct;2(41):7149-7159 10. [IF=6.057] Zhihong Li et al."New MS network analysis pattern for the rapid identification of constituents from traditional Chinese medicine prescription Lishukang capsules in vitro and in vivo based on UHPLC/Q-TOF-MS."Talanta. 2018 Nov;189:606 11. [IF=4.759] Yu-Xiu Yang et al."pH-dependent surface electrostatic effects in retention on immobilized artificial membrane chromatography: Determination of the intrinsic phospholipid-water sorption coefficients of diverse analytes."J Chromatogr A. 2018 Oct;1570:172 12. [IF=4.759] Yanyan Zhang et al."Rapid screening and identification of monoamine oxidase-A inhibitors from Corydalis Rhizome using enzyme-immobilized magnetic beads based method."J Chromatogr A. 2019 May;1592:1 13. [IF=4.411] Jinjun Shan et al."Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum."Molecules. 2018 Jul;23(7):1634 14. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239 15. [IF=3.659] Rong Qian et al."In vitro and in vivo bactericidal activity of Tinospora sagittata (Oliv.) Gagnep. var. craveniana (S.Y.Hu) Lo and its main effective component, palmatine, against porcine Helicobacter pylori."Bmc Complem Altern M. 2016 Dec;16(1):1-8 16. [IF=2.896] Shun Liu et al."Effects of ultrahigh pressure extraction conditions on yields of berberine and palmatine from cortex Phellodendri amurensis."Anal Methods-Uk. 2013 Aug;5(17):4506-4512 17. [IF=1.618] Li Jiang-Yan et al."Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods."J Chromatogr Sci. 2015 Aug;53(7):1131-1139 18. [IF=5.81] Zhao Jing et al."Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice."Front Pharmacol. 2021 Jun;0:1426 19. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51 20. [IF=3.935] Yang Song et al."Pharmacokinetics tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry."J Pharmaceut Biomed. 2021 Sep;203:11422 21. [IF=3.463] Xiao-Meng Liu et al."Comparative transcriptome analysis provides novel insights into the molecular mechanism of berberine biosynthesis in Coptis chinensis."Sci Hortic-Amsterdam. 2022 Jan;291:110585 22. [IF=3.373] Xueyan Zhao et al."An integrated strategy for the establishment of a protoberberine alkaloid profile: Exploration of the differences in composition between Tinosporae radix and Fibraurea caulis."Phytochem Analysis. 2021 Nov;32(6):1131-1140 23. [IF=2.351] Juanjuan Liu et al."Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris."Biofouling. 2020;36(3):319-331 24. [IF=1.345] Ya-Li Zhang et al."Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells."J Asian Nat Prod Res. 2020;22(5):452-463 25. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 |
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